OnabotulinumtoxinA ( Botox ), also called botulinum toxin type A , is made from the bacteria that causes botulism. Botulinum toxin blocks nerve activity in the muscles, causing a temporary reduction in muscle activity.
Duration of response was calculated as the number of days between injection and the date of the first visit at which patients returned to 3 or 4 on the HDSS scale. The median duration of response following the first treatment in BOTOX treated patients with either dose was 201 days. Among those who received a second BOTOX injection, the median duration of response was similar to that observed after the first treatment.
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Of 1242 overactive bladder patients in placebo-controlled clinical studies of BOTOX, 41.4% (n=514) were 65 years of age or older, and 14.7% (n=182) were 75 years of age or older. Adverse reactions of UTI and urinary retention were more common in patients 65 years of age or older in both placebo and BOTOX groups compared to younger patients (see Table 17 ). Otherwise, there were no overall differences in the safety profile following BOTOX treatment between patients aged 65 years and older compared to younger patients in these studies.
Almost every year, I go to Paris for the International Master Course on Aging Skin (IMCAS), and Dysport has been talked about for a number of years there. After a review of the data and talking to European physicians, I’d surmise that the only difference seems to be that Dysport injections may not last quite as long as Botox and may be more painful. Time will tell.
All children injected in our clinic have done very well immediately following the injections and are sent home without any emotional upset. We seldom use sedation; rather, we use distraction and quick injection technique. In rare cases, localization of a muscle may be necessary using an electromyograph machine (EMG) or electric stimulator, this would be discussed with family prior to scheduling the injections.